Préime powered by performance, potency and purity

Drawing on more than 20 years of professional skincare experience, the Préime portfolio is meticulously crafted to meet the latest skincare needs in regenerative aesthetics.

Préime – pronounced pre-may – is the latest professional skincare brand to hit Australian shores. Hailing from Dublin, Préime is currently in 30+ countries and is rapidly expanding around the globe.

The impressive portfolio – which includes Préime DermaCeuticals for in-clinic and Préime DermaProfessional for homecare – is designed to work both as standalone treatments and in tandem with aesthetic treatments.

Using the latest active ingredients and technology, including human umbilical cord blood exosomes, Préime solutions and homecare products are designed to target specific skin concerns, helping to improve skin health, barrier function and overall skin quality.

Préime’s innovative approach meets the growing demand for non- invasive, regenerative skincare. The combination of bespoke skincare cocktails with advanced delivery systems offers outstanding results – and empowers clinics with the tools to adapt to changing market trends and confidently offer their patients a regenerative approach to skin health.

Préime is also pioneering sustainability in aesthetics. It is the first company in the industry
to offset its plastic footprint in collaboration with 4Ocean. For every product sold, one pound of rubbish is removed from the world’s oceans, rivers and coastlines, making Préime a leader in responsible manufacturing practices.

Préime DermaCeuticals

Préime DermaCeuticals is a curated range of professional solutions that deliver the potency of clinically proven active ingredients in their purest form. Powered by Pure TechnologyTM, the Regenerative range uses cutting-edge restorative ingredients – exosomes and nucleotides – to help activate the skin’s natural rejuvenation processes for a global anti-ageing effect.

The expertly designed and scientifically formulated Cocktail solutions combine peptides, vitamins and botanicals to assist in refining the skin’s quality for a radiant, balanced and healthier- looking complexion.

Delivering targeted, results- focused solutions, Préime DermaCeuticals can be used as standalone treatments or to enhance the outcomes of other aesthetic devices and procedures.

Préime DermaProfessional

Préime DermaProfessional is a concise homecare range of clinically-backed formulations designed to extend and enhance the results achieved in-clinic. Featuring powerful, high- performing active ingredients and advanced delivery systems, each product in the Préime DermaProfessional range has been carefully crafted to allow a seamless continuation of any in-clinic Préime treatment at home.

‘POWERED BY PURE TECHNOLOGY™, THE REGENERATIVE RANGE USES CUTTING-EDGE RESTORATIVE INGREDIENTS – EXOSOMES AND NUCLEOTIDES – TO HELP ACTIVATE THE SKIN’S NATURAL REJUVENATION PROCESSES.’

What is the role of human-derived exosomes in skin rejuvenation and regeneration?

Exosomes, both endogenic and exogenous, are being explored for their potential to repair, regenerate and rejuvenate skin tissue. They carry bioactive molecules that can influence various cellular processes essential for skin health. They are powerful molecules that up- and down-regulate critical processes of cellular repair, and also have a key role in reducing cellular senescence.

Exosomal therapy is emerging as a novel treatment option in regenerative aesthetics, the newest sub-category in the aesthetics world today. The secretome of human-derived stem cells, which includes exosomes, contains growth factors that have strong mitogenic activities, aiding in healthy tissue regeneration and skin rejuvenation. In short, a pure exosome will find damage and either repair it, or eliminate it, and will find healthy cells, and promote healthy growth
of more of those cells.

Exosomes can activate signalling pathways like Wnt/β-catenin, which are important for skin regeneration. This activation helps in the repair and rejuvenation of skin tissues. Human-derived exosomes, particularly from sources like umbilical cord blood plasma, have shown specific and improved regenerative capabilities, making them promising for therapeutic applications in skin regeneration and rejuvenation.

What are the main advantages of using exosome therapy for skin rejuvenation?

Skin heals better, faster. Using an exosome concomitantly with an aesthetic treatment reaches places that aesthetic devices may be challenged by, making them the preferred combination for accelerated stronger repair and better outcomes.

Why did you choose to work with Préime?

I chose to work with Préime DermaCeuticals and Préime DermaProfessional because their exosome is unique, and purity was top of mind. Additionally, I really like their approach to exosome technology, research and formulations as a whole. I am a physician first, and science matters. This is a brand-new field, and everyone is racing to be the first man on the moon. The team at Préime have taken their time to do things the right way, and that really stood out for me.

How does Préime’s Pure Technology™ work and what makes it valuable as a topical skin treatment?

Pure TechnologyTM is exactly that – it is pure. When it comes to exosomes, source is very important, but there are other important elements, too, such as how the exosomes are derived, stored and processed. Préime has gone to great lengths to ensure that their exosome is minimally processed, and alleviates the need altogether to go to cell culture and introduce foreign protein medium like many other brands do. This allows us to get better outcomes with less material, so we can truly target regenerative sites in skin.

Can you comment further on Préime’s sourcing and extraction methods and why this is important to the end product?

Préime’s exosome is derived from human umbilical cord blood plasma. Their patented extraction process derives the exosome directly from the blood, allowing for the purest harvest possible. This allows them to completely skip going to cell culture, as well as alleviate the introduction of foreign bovine serum, removing sources of contamination and additional particulate ending up in the final formula. This gives me the confidence that the product is pure, and I can be comfortable with what is going onto my patient’s skin. The end product is also reported to be highly stable due to the extraction process, which is important when it comes to working with proteins.

How do you use Préime’s exosome products in practice?

We use them in conjunction with our top aesthetic treatments and procedures, including both ablative and non-ablative lasers, as well as with microneedling. They are also given for daily-use homecare to maintain results at home.

What results have you been observing both as an adjunct to other cosmetic procedures and as a standalone treatment?

In a pilot study we recently did on Préime’s Pure exosome, we saw results in both groups – laser plus exosome, as well as exosome alone with no laser treatment. This is impressive because previous thinking maintained that you need some form of assisted delivery to get great results out of an exosome. However, in this case, due to the small size of exosomes, as well as the purity of Préime’s product, we are able to see regenerative benefits without being paired with an aesthetic treatment.

When combined with an ablative laser treatment, we identified the skin heals faster as compared to traditional standard emollient post care and the results are remarkable. Blinded evaluators noted improvement in wrinkle depth, hyperpigmentation and overall skin volume. Additionally, the majority of the treated patients said they were very satisfied with the outcome, and they would recommend it to a friend. We are now starting a more comprehensive study to further evaluate the efficacy based on the pilot trial insights.

Any final thoughts on exosomes?

What was once disregarded as a cellular trash remover, exosomes may be the key opening up the door towards the next revolutionary breakthrough in medicine. AMP

‘USING AN EXOSOME CONCOMITANTLY WITH AN AESTHETIC TREATMENT REACHES PLACES THAT AESTHETIC DEVICES MAY BE CHALLENGED BY, MAKING THEM THE PREFERRED COMBINATION FOR ACCELERATED STRONGER REPAIR AND BETTER OUTCOMES.’