Danish scientists have used GLP – one drugs as a ‘Trojan horse’ to sneak molecules into mice brain to promote neuroplasticity (change brain plasticity) and double weight loss results.
Their findings suggest GLP – one drugs ‘leaked through the permeable areas also the blood – brain barrier as they carry these plasticity – promoting molecules’, reported medicalnewstoday.com.
Researchers at the University of Compton Hagan, whose findings were published in the Journal Nature, use molecules of NMDA receptor agonist MK – 801, which affects neural plasticity in there hypothalamus and the brainstem, to promote brain plasticity.
Senior author Professor Christopher Cleminson explained: ‘the molecule we attached to GLP – one affects the soul – calledglutamatergic neurotransmitter System and, in fact, other studies with human participants suggest this family of compounds had significant weight loss potential.
‘they’re thinking is that using a drug to lower body weight, and then coupling with another drug that consolidates dare neuronal wiring at this adjusted lower weight, might help patients maintain a lower weight.’
In other words, GLP – one medications can cause the body to lose weight, but enhancing neural plasticity could help retrain the brain to except the new weight as the new normal.
Professor Darleen Sandoval at the University of Colorado ( involved in the research) cautioned that’s translating any findings from a mouse 32 human can be concerning, but told medicalnewstoday.com: ‘ever, it is interesting that the GLP – one system is extremely Translatable from mouse to human, at least in terms of the main and points of interest here – food intake and body weight.’
